Brandon J Aubrey Selected Research

Proteins (Proteins, Gene)

12/2023	Mezigdomide is effective alone and in combination with Menin inhibition in pre-clinical models of KMT2A-r and NPM1c AML.
1/2021	Intact TP-53 function is essential for sustaining durable responses to BH3-mimetic drugs in leukemias.
10/2016	The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models.
3/2015	An inducible lentiviral guide RNA platform enables the identification of tumor-essential genes and tumor-promoting mutations in vivo.

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Brandon J Aubrey Research Topics

Disease

8	Neoplasms (Cancer) 12/2023 - 01/2014
5	Lymphoma (Lymphomas) 12/2023 - 01/2014
4	Leukemia 01/2022 - 10/2016
2	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 12/2023 - 01/2021
1	Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor) 01/2022
1	Hematologic Neoplasms (Hematological Malignancy) 01/2021
1	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 01/2021
1	Hepatocellular Carcinoma (Hepatoma) 01/2018
1	Multiple Myeloma 10/2016
1	Burkitt Lymphoma (Burkitt's Lymphoma) 03/2015

Drug/Important Bio-Agent (IBA)

4	Proteins (Proteins, Gene)FDA Link 12/2023 - 03/2015
2	ChromatinIBA 01/2022 - 01/2022
1	NucleophosminIBA 12/2023
1	Lysine (L-Lysine)FDA Link 12/2023
1	MethyltransferasesIBA 12/2023
1	ArrestinIBA 12/2023
1	antineoplaston A10 (A 10)IBA 01/2022
1	Transcription Factors (Transcription Factor)IBA 01/2022
1	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 01/2022
1	venetoclaxIBA 01/2021
1	InterferonsIBA 01/2019
1	2- Fluoro- N'- (3- fluoro- 5- (pyridin- 2- yl)benzoyl)benzenesulfonohydrazideIBA 01/2018
1	2-(phenylsulfonyl)hydrazide 4-fluoro-5-methyl- (1,1'-Biphenyl)-3-carboxylic acidIBA 01/2018
1	S63845IBA 10/2016
1	Tumor Suppressor Protein p53IBA 01/2016
1	Bcl-2-Like Protein 11IBA 01/2016
1	Complement System Proteins (Complement)IBA 01/2016
1	RNA (Ribonucleic Acid)IBA 03/2015

Therapy/Procedure

4	Therapeutics 12/2023 - 01/2014